Ethoxyphenylamidomethane sulfonate.



:3 L n w:

s PATENT. onnien;

Sneci cation of Letters Patent.

osnnwo Lniiug at i i i :vented new an-cl useful Elliot sinidoino ioMenufollowing J11. crystallize-fl compounds which allowing aromaticamido A to react on bisulfites and for- 'inslclchyde as l have describedin o sealed letter in the year 1900 published in the lloveniher 1905number of the Bulletin de la Socez'c imZuszwieZ-Ze (Z Madhouse, pages379 to 384: I love new found that s compound belonging to this seriw andnot having yet been described or pi'epziieclresulting" from c on ofpsra-phenetidin on formal- Toisulfite of soda, has valuable l'vrooerties. This comby the mutual action of lehycle bisnlfites hecoupe-lino may be pre of pemphenetidin adding hisulfite o. by addingformelco of psrsplieneticlin with king to psmpheneticin a re andformaldehyde and i The reaction which takes place ieprsescnte l hythefollowing eque- 1 NsHEiQ GH U E hoxyphenylmidomethone sulfonoto ofsodium.

I l 1 .i I

T0 TH? Application filed June 2?, 19GB. Florisl No. is-0,696

in the King on LEI 'E'TIT, DOLLFUS mine-in, ITALY.

I l/IlElTE-iANE EULFQNATE.

Petenteo Slept. 2i, (Specimens) Welsh them with alcohol. The product sooh I tamed is a mass of White crystals which oil ter drying contain 1"molecule of ester CPYS$StllIZQLiLlOR1 the analysis shows a con- I tentof 6.67% Water instead of the theore ical amount (if-6.64% fore compoundof'the i formula I co ce s on-ion so ns+n o' This formula is fixeo fromthe result of the estimation of the amounts of carbon hydrogen, nitrogenand sulfur, obtained by complete analysis of the new compouno which isconsequently a pamethoxyphenylmnidomethene. sulfonate' of sodium.

The new compound is colorless, inodorous anal has a, saline taste whichafter a certain length of time is replaced by a pure sweet taste whichlasts a long time it is easily soluble in water; an addition of acid tothe aqueous solution causes the preoipitetion of the less solubleethoxyphenylemidomethene sulfonic acid. If some drops of e solutiontsini-ng about one half of one per cent. of an ethoxyphenylemidornethonesulfonete, s iiright purple color is yielded; cliroinic ecicl andClilOICld of golol give the some reaction, By cooling some bichtomate ofpotash to a COlil diluted. solution contsining hydrochloiicl ofparamiclophenol, hydrochloric acid anal a very small amount ofethoxypheuylamidomethene sulfonete of soda, a bright blue color appears.The same characteristic reactions ai'c shown by any other soluble l ofLGlTlC chlorid are added to a solution c0n= salts of theethoxyphenylemidomethune sulfonic sold as they may be oloteined eitherby double decomposition with the sodium. sell; or by using in themanufacture of the new compound other soluble bisulfites in the requiredproportion instead of leisulfite of?" soils.

Careful pharmacological experiments have shown that the new compoundliss very vol ushle properties and affects the heart less than othersimilar compounds heretofore ln'iown. s y

/Vhe T cl E i "1 es inveilion and tlesire to seen by if iers Patent,is:- A" s new article of menufscture, the ii fliflilGOletiioxyphenylsmitlomethene snlion ete of sodium corresponding to theDennis crystals by means of a vacuLLu and losing colorless, inodoious,easily soluble in inc ill)

Water, ahd giving in aqi eous oolu tion on ad dition of acids thepreclpitation ofetl oxyphenylamidomethane sulfonic acid,

2. The process of preparing etliomphenyl- 5 amidomethane sulfonate ofthe alkalies,

which consists in mixing together one moioo ular proportion ofpamphonetidin in solution, one molecular proportion of fol waldo hyde,and one molecular proportion-of o, loi- 10 sulfite of an alkali metal,heating the mixture and allowing it to cool.

3. The process of preparing ethoxyphenylamidomethene sulfonateof'sodium, which consists in alissolving one molecular proportion ofpmraphenetidin in alcohol, adding one molecular proportion offormaltlehycie in. aqueous solution anal then adding one molecularproportion of bisulfite of sodlium, heat imp; the mixture to the boilingpoint am allowing to cool In testimony whereofl al'fix myeignes we inpresence of two Witnesses.

RGBERTO LEIPEHT. Witnesses MICHAEL SIERSDORFER, J 1: E. LEPETIT.

